The NtrYX Two-Component System Regulates the Bacterial Cell Envelope

A photosensory two-component system regulates bacterial cell attachment.

Flavin-binding LOV domains are blue-light photosensory modules that are conserved in a number of developmental and circadian regulatory proteins in plants, algae, and fungi. LOV domains are also present in bacterial genomes, and are commonly located at the amino termini of sensor histidine kinases. Genes predicted to encode LOV-histidine kinases are conserved across a broad range of bacterial t...

The bacterial cell envelope.

The CpxAR Two-component System Regulates a Complex Envelope Stress Response in Gram-negative Bacteria

e CpxA membrane bound sensor kinase utilizes a periplasmic sensing domain to detect a wide variety of stresses to the bacterial envelope. !is information is communicated via typical two-component phosphotransfer mediated reactions to the response regulator CpxR. Phosphorylated CpxR binds upstream of numerous promoters to mediate adaptation. Initial studies of CpxA inducing signals and CpxR regu...

Osmosensing by the bacterial PhoQ/PhoP two-component system

The PhoQ/PhoP two-component system plays an essential role in the response of enterobacteria to the environment of their mammalian hosts. It is known to sense several stimuli that are potentially associated with the host, including extracellular magnesium limitation, low pH, and the presence of cationic antimicrobial peptides. Here, we show that the PhoQ/PhoP two-component systems of Escherichi...

The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide.

We demonstrate that the twin arginine translocation (Tat) system contributes to bacterial resistance to cationic antimicrobial peptides (CAMPs). Our results show that a deletion at the tatC gene, which encodes a subunit of the Tat complex, caused Salmonella and Escherichia coli to become susceptible to protamine. We screened chromosomal loci that encode known and predicted Tat-dependent protein...